Caryophyllene’s was found in one animal study to reduce pain from inflammation and nerve pain, and the researchers suggested that it might be useful in treating long-term chronic pain. This is likely due to the terpene’s unique molecular structure that allows it to bind easily to CB2 receptors. CB2 receptors are found in the peripheral endocannabinoid system, rather than the brain, which mean it can help reduce inflammation without making a user high.
The terpene is also commonly found in cloves, black pepper and cinnamon, and in some ways the high from cannabis strains with high levels of Caryophyllene can be said to mimic this, with users saying it provides feelings of warmth and spice. Terpenes are also responsible for the aromatic proprieties of plants and that is why Caryophyllene-dominant cannabis strains are said to have an aroma similar to cinnamon and cloves.